Best Drain Cleaner for Main Line 2021: Review and Buying Guide

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When it comes to your main line, you need to be extra careful, and keep an eye out for potential clogging, because if this happens, it can mess you up in ways you could never imagine, yet, most people never think about it until it actually happens.

Best Drain Cleaner for Main Line

Product Specs Price

Roebic Laboratories, Inc. K-97 Main Line Cleaner

  • Naturally breaks down waste
  • Ideal for low flow toilets
  • Manufactured in United States
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​Bio-clean Drain Septic Bacteria​

  • DIGESTS dead organic waste
  • DIGESTS dead organic waste
  • 100% natural
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Instant Power 1969 Drain Opener

  • Works on drains, sewer lines, grease traps, and septic system
  • 20 times stronger than common drain openers
  • Made in USA
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Liquid-Plumr Pro-Strength Full Clog Destroyer

  • Dissolves hair, soap scum build up, food and other organic matter
  • Non-corrosive, septic safe
  • PipeGuard technology protects pipes
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Green Gobbler Ultimate Main Drain Opener

  • Works within minutes
  • Odorless and non-flammable
  • Maintains free flowing pipes and drains
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Best Drain Cleaner for Main Line Review

1. Roebic Laboratories, Inc. K-97 Main Line Cleaner

This is a powerful product from Roebic Laboratories Inc. that will work well on your main sewer line.

It is made up of millions of powerful bacteria that can damage any waste complete in order to unclog your backed-up system and restore order back to your drainage.

It can safely be used in your sewer and septic tanks, and in addition, you can use it in your bathroom as well as kitchen sinks, because it digests paper, grease, and fats. Using this drain cleaner on a weekly basis will ensure that your low-flow toilet never clogs again.

It is a biodegradable product, and therefore safe for the environment and anyone who uses it. This is because it causes less pollution and ensures that all the non-toxic elements are broken down efficiently and they do not turn into poison.

It is safe to use on any type of pipes because it is non-corrosive.

It is very easy to use; Here’s how to use it:

  1. Ensure the cap is secure and inverted.
  2. Pour out ½ of contents into the drain.
  3. Leave it for 30 minutes.
  4. Clear out by running water through it.

Bottom line: This is an extremely powerful product to use for your drain cleaner, and therefore, you need to take all of the necessary precautionary measures while using it.

Use a heavy-duty glove, goggles as well as an apron before even opening the bottle. I highly recommend it, especially in main sewer lines that are showing signs of almost clogging.

2. Bio-clean – Drain Septic Bacteria for Septic Tanks and Main Line

This is one of the best products for your main sewer line, because it contains a very special combination of enzymes and bacteria that will digest almost all of the dead organic waste that is found in your plumbing system with the potential of causing a blockage.

Because bacteria are everywhere, this drain cleaner works in destroying the most harmful of it. You can actually pour it down your drains from time to time to keep everything okay and working great.

If you suspect your main line is about to clog, or if you want to prevent the problem before it happens, this drain cleaning product will sort this problem out for you.

You can pour it in all your drains, in the bathroom, kitchen and even toilet, and leave it to work its magic, because it is not limited to any specific type of gunk. It clears it all, from grease, to paper, to soap scum, etc.

It can be used for residential purposes as well as commercial, and the contents in the container guarantees up to 100 uses.

It is environmentally safe and friendly, which is what you need for a sewer treatment, due to the disposal process. This ensures that wherever the waste goes, it will not cause any further damage to the environment.

Perhaps what you will love most about it is that it is 100% natural, and does not contain even a drop of chemicals, which is what you need in a drain cleaner that shall be used in most of your home. This also makes it bio-degradable.

It does not produce any fumes or heat when being used.

Bottom line: I would recommend this product any day, especially for most of the reasons listed above, most especially the fact that it is all natural. The only downside is that it is a tad expensive, if you compare with other chemical products, but, in this day and age, we have all come to appreciate the fact that natural products come with a bit of a price tag attached, but its all worth it.

3. Instant Power 1969 Hair and Grease Drain Opener

This is a product designed specifically for the main sewer line. It will help in clearing the clog and ensure that the flow of water is restored to your main line.

It is made with a non-acidic formula, which is what you need when dealing with most of your household fixtures, but, this does not make it any less powerful.

In fact, it is so powerful that it works in restoring order to your drainage system with just one application.

It is ready to use, straight from the store. You need not mix it with water or any other products for it to become active. That’s how simple it makes things for you. One container has 1 liter of the drain cleaner, and so you can get some very good use out of it.

This product is safe and suitable for all types of drains and pipes. You shall not have any incidents of the pipes getting destroyed or getting corroded as a result of using the drain cleaner, and if the customer’s reports are anything to go by, this is a product that works each and every time.

You will find the instructions on how to use it clearly written on the bottle, but, as stated above, it is not a complicated process. The only downside to using this product is that is doesn’t come with a warranty from the manufacturer in case it does not work, but then again, most liquid products rarely ever do have a warranty.

Bottom line: For your main sewer line, I highly recommend this product. You will, however, need to leave it overnight for it to be effective in your septic tank.

4. Liquid-Plumr Pro-Strength Full Clog Destroyer

As the name suggests, this drain cleaner from Liquid-Plumr will destroy all of your clog related problems in a matter of minutes.

It is pro-strength and therefore perfect for the main sewer line.

It has a pipe guard synthesized chemical that will protect your entire plumbing system from all future clogs, and even prevent the build-up of any such gunk.

You can choose from its different sized bottles, as they are available in 80oz, 218oz and 32oz., Whichever one you like.

It can work perfectly with pipes made of plastic, metal, copper and PVC pipes. It will not destroy them.

It will also fight odors for you, and leave your system smelling fresh within 15 minutes. You can imagine how great this point is for your main sewer line that may already be emitting a foul smell.  After pouring it down the drain, make sure to clean it out with some hot water.

The liquid is thick and does not splash around, plus it will remain in your system for a few days to ensure there are no further clogs.

Bottom line: This product works on almost all types of clogs, but, if you want to save on cost, it is advisable to purchase it in bulk, otherwise, it can be pretty expensive. I highly recommend it for your main line.

5. Green Gobbler Ultimate Main Drain Opener + Drain Cleaner

I have definitely saved the best for last.

This is the real deal when it comes to main lines, because it has been designed for such kind of complicated problems.

It is extremely powerful and will do the job for you in a matter of minutes, and that sewer line that was threatening to clog will be perfectly fine. You don’t need to worry.

With this dual-chambered bottle from the green gobbler, there is no measuring and no messes. Depending on your clog, you simply need to pour out one chamber of the liquid at a time in your drains and you are good to go.

Now, the manufacturer recommends that you use one whole chamber for your most troubling drains, but for your toilet and main sewer, you will need to use the entire contents.

It is very easy to use, and it works fast as well. Once you pour out the contents into your drains, you will need to wait just a few minutes then you flush it and the clog will be as good as gone.

This product will dissolve clogs very fast, because the technology used works on contact. It will ALSO liquefy any other clog-causing obstructions such as oil, fats, hair, and lint.

This high-density formula is heavier than water and it will sink and cling to your drain and remain there for a couple of days to ensure the blockage does not happen again.

It is biodegradable and will not harm the environment when it is disposed of. In addition to this, it is odorless, non-flammable, and non-corrosive. After each use, it will not leave a foul chemical smell behind or destroy your pipes.

Bottom line: This product is great for unclogging your main drains and the best part about it is that it is biodegradable for anyone who cares about marine life. It has been tried and tested numerous times and each time it passes the test because it eliminates clogs in a very short time.

It is however very thin in consistency compared to other drain cleaners, and as a result, you may end up using a whole lot more than you had planned.


This is how you know that your main line is actually blocked.

Multiple drains in your house will be backed up:

Now, your home’s sewage system is like a tree with a root system where multiple drains stem from. If the trunk gets blocked, it will eventually affect all the attached branches as well. This water will back up and spread to all the attached drains, because it has nowhere to go except back to where it came from.

Another sign for this will be a loud gurgling noise that will be heard coming from the showers, bathtub and sinks. This is a result of waste water hitting the air pockets as it tries to slowly move past the clog and hence forced burbles to the surface of the water.

When you notice this happening, stop using your sinks immediately, because the more water you flush down your drains, the louder the gurgling will be.

You will notice a strong sewage smell coming from your plumbing fixtures:

The smell of sewage is definitely an unmistakable one, and nobody wants this unpleasant odor throughout their entire house. If you ever notice this foul smell, the likelihood is that your main line is clogged up.

Water will begin to over flow:

If your main line is blocked, then water will back up and start overflowing in the other sinks as well. You may notice sewage water in your kitchen sink, your bathtub, your shower, etc. It is quite a disgusting and irritating affair.

Here’s how you can check for this if you suspect the main line has a clog;

  1. Turn on the water in the bathroom sink and check to see if the water will rise.
  2. Flush the toilet in your bathroom and check if there is water coming up through the bathtub.
  3. Turn on the washing machine and check if water will come up through the other fixtures.

Now, if water comes up through your toilet or bathtub, then something is definitely wrong with your main line, because water should flow out, not come back.

Check if there is water in your home sewer:

Most modern homes will have a sewer clean out. This is normally marked with a circular lid most likely made out of plastic or concrete, and it will be written “clean out” or something of the sort.

Locate, remove the cap, and check the level of standing sewer water. If you see the water standing and not flowing out, you have a problem in your hands.

Things To Look Out For When Buying Drain Cleaners for the Main Line

If your main sewer line is already clogged and water has started to flow back into the other fixtures, then it is probably too late to do anything other than call the plumber to come and help you sort out the mess.

If you just suspect that something is wrong, then you need not wait till it gets worse, you need to buy a good quality drain cleaner, to clear out the clog in your system and restore order back into your home.

A good quality drain cleaner for a main sewer line should have the following qualities;

It should be strong enough: The main line in your home handles a lot of waste, and as such, a clog could be made up of virtually anything under the sun, and it may be difficult to put a finger to what is exactly causing the blockage.

The best drain cleaner would be one that is very powerful and strong enough to dissolve and liquefy all of the different types of clogging materials and leave your drains clean and clear.

It should be environmentally safe: Remember that the sewer water needs to be disposed of in a proper manner, and therefore any substances you use in this water should be safe for the environment. This is a very important point, because you do not want to do more harm than good.

It should be easy to use: The fact that it is strong and powerful should not necessarily make it complicated and dangerous to handle that you will need to get some exterminators.

No. In fact, you can find some pretty great natural stuff to help you out with this.

While most will require you to put on some protective clothing, we are talking simple stuff like goggles, gloves, eye wear and an apron, not a full-on gas mask that will even scare the kids.

It should be quick acting: This is essential if you are suspecting that something messy is about to go down. You simply need to think about your precious kitchen sink and bathtub overflowing with sewage water, and you go crazy.

Look for a product that will work fast, preferably in a couple of minutes and restore order, not a product that will need to be left on for 24 hours before it becomes active.

Final thoughts on the Best Drain Cleaner for Main Line

For your main sewer line “prevention is better than cure” that should always be your motto. Other than natural causes, preventing the main line from clogging can be very easy, it simply means that you should be careful with whatever you let pass through your drains.

Also, ensure to give it some treatment every now and then, even though there is no clogging, just to make sure that any waste matter that may be present is broken down and eliminated before it becomes a problem. You can have a schedule of treating it once a month.

When it comes to your kitchen, be careful with food particles, grease and other substances that should never pass through. For the bathroom and bathtub, ensure not to use them when you have sand, or dirt because it will all go down the drain and lead to a clog.

Your toilet is the most sensitive and you should avoid flushing anything that is not supposed to be flushed, including wet tissues and other hard papers that will come back to haunt you later.

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